Woodward successfully completed the synthesis of erythromycin A. === Erythromycin related compounds === Azithromycin Carbomycin Cethromycin Clarithromycin Dirithromycin Mitemcinal Oleandomycin Roxithromycin Spiramycin Telithromycin Tylosin == History == In 1949 Abelardo B.
It is in the macrolide family of antibiotics and works by decreasing bacterial protein production. Erythromycin was first isolated in 1952 from the bacteria Saccharopolyspora erythraea.
The product was launched commercially in 1952 under the brand name Ilosone (after the Philippine region of Iloilo where it was originally collected).
McGuire, managed to isolate erythromycin from the metabolic products of a strain of Streptomyces erythreus (designation changed to Saccharopolyspora erythraea) found in the samples. Lilly filed for patent protection on the compound which was granted in 1953.
Erythromycin was formerly also called Ilotycin. The antibiotic clarithromycin was invented by scientists at the Japanese drug company Taisho Pharmaceutical in the 1970s as a result of their efforts to overcome the acid instability of erythromycin. Scientists at Chugai Pharmaceuticals discovered an erythromycin-derived motilin agonist called mitemcinal that is believed to have strong prokinetic properties (similar to erythromycin) but lacking antibiotic properties.
In 2017, a Kaiser Health News study found that the per-unit cost of dozens of generics doubled or even tripled from 2015 to 2016, increasing spending by the Medicaid program.
Due to price increases by drug manufacturers, Medicaid paid on average $2,685,330 more for Erythromycin in 2016 compared to 2015 (not including rebates).
In 2017, a Kaiser Health News study found that the per-unit cost of dozens of generics doubled or even tripled from 2015 to 2016, increasing spending by the Medicaid program.
Due to price increases by drug manufacturers, Medicaid paid on average $2,685,330 more for Erythromycin in 2016 compared to 2015 (not including rebates).
In 2017, it was the 215th most commonly prescribed medication in the United States, with more than two million prescriptions. == Medical uses == Erythromycin can be used to treat bacteria responsible for causing infections of the skin and upper respiratory tract, including Streptococcus, Staphylococcus, Haemophilus and Corynebacterium genera.
In 2017, a Kaiser Health News study found that the per-unit cost of dozens of generics doubled or even tripled from 2015 to 2016, increasing spending by the Medicaid program.
By 2018, generic drug prices had climbed another 5% on average. ===Brand names=== Brand names include Robimycin, E-Mycin, E.E.S.
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