MAOIs became widely used as antidepressants in the early 1950s.
Originally intended for the treatment of tuberculosis, in 1952, iproniazid's antidepressant properties were discovered when researchers noted that the depressed patients given iproniazid experienced a relief of their depression.
The discovery of the 2 isoenzymes of MAO has led to the development of selective MAOIs that may have a more favorable side-effect profile. The older MAOIs' heyday was mostly between the years 1957 and 1970.
The discovery of the 2 isoenzymes of MAO has led to the development of selective MAOIs that may have a more favorable side-effect profile. The older MAOIs' heyday was mostly between the years 1957 and 1970.
MAOIs appear to be particularly effective in the management of bipolar depression according to a retrospective-analysis from 2009.
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